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BioDenta® Clinical Evidence

Your oral care deserves more than just claims – it deserves proof.

BioDenta™ Clinical Evidence

Your oral care deserves more than just claims – it deserves proof.

Science You Can Trust

BioDenta® is built on science, not trends. Our probiotic strains, fluoride levels, and toothbrush designs are selected based on clinical evidence and proven results. Explore the research behind our products below.

Probiotic Toothpaste & Mouthrinse

Supports gum health and balances the microbiome — naturally.

Clinical studies show probiotic toothpaste and mouthrinse can reduce gum inflammation and bleeding, lower harmful bacteria like Streptococcus mutans, reduce the risk of cavities, and support a healthier oral microbiome — all without side effects.

Probiotics for Fresher Breath

Targets the root cause of bad breath — not just the symptoms.

Trials demonstrate that Lactobacillus salivarius and L. plantarum reduce volatile sulfur compounds (VSCs), improve breath scores, and rebalance the oral microbiota. Benefits have been observed in both adults and orthodontic patients with halitosis.

For Children & Teens

Reduces cavity-causing bacteria and plaque buildup in young mouths.

Children and teens using probiotic oral care showed significant reductions in Streptococcus mutans and slower plaque regrowth compared to those using conventional products — protecting smiles even with sugary diets and imperfect brushing habits.

Safe for Children & Pregnant Women

Trusted ingredients backed by safety studies and clinical guidelines.

Fluoride toothpaste at 500 ppm is recognized as safe for children when used under supervision. Studies also show probiotic strains are safe during pregnancy and lactation, with no reported adverse effects, while reducing maternal plaque and gum disease.

Oral Microbiome & Systemic Health

A healthy mouth supports a healthier body — from heart to brain.

Research links oral microbial imbalance to systemic conditions such as cardiovascular disease, diabetes, respiratory infections, and preterm birth. Probiotics support immune function, reduce inflammation, and maintain microbial harmony for broader health benefits.

Probiotics for Braces & Orthodontics

Supports fresher breath and healthier gums during orthodontic treatment.

Orthodontic patients using probiotic oral care products experienced reduced halitosis, improved gum scores, and better plaque control compared to placebo — offering valuable support where traditional cleaning is more challenging.

Xylitol for Caries Prevention

Proven to reduce cavity-causing bacteria in children’s saliva.

Xylitol, a natural sugar alternative, reduces the levels of Streptococcus mutans and helps prevent cavities. Studies show children using toothpaste with xylitol and probiotics experienced lower bacterial counts and better oral health outcomes.

Synbiotics in Oral Care

Probiotics + Prebiotics: the next step in oral care.

Emerging evidence suggests combining probiotics with prebiotics (synbiotics) enhances their effectiveness — reducing cavity-causing bacteria, supporting healthier biofilm, and providing longer-lasting microbial balance.

Bamboo vs. Plastic Toothbrushes

Proven hygiene with less plastic – better for you and the planet.

Bamboo toothbrushes retain fewer bacteria than plastic after regular use. Clinical studies confirm their hygiene is comparable or better, with no increased microbial risk — making them a safe, eco-conscious choice for daily brushing.

Toothbrush Bristle Type Matters

Soft bristles strike the ideal balance between cleaning power and gum protection.

Systematic reviews and clinical trials show soft and ultra-soft bristles are just as effective at removing plaque as medium bristles, while being gentler on gums and safer for oral tissues — reducing abrasion without compromising cleanliness.

Sources & Reference List​
    1. Lee MK, Chen IH, Hsu IL, Tsai WH, et al. The impact of Lacticaseibacillus paracasei GMNL 143 toothpaste on gingivitis and oral microbiota in adults. BMC Oral Health. 2024.
    2. Lee MK, Chen IH, Hsieh YS, et al. Effects of toothpaste containing inactivated L. paracasei on gingivitis. Int J Environ Res Public Health. 2022;22(1):72.
    3. Tahir K, Abul Barakaat A, Ali US, et al. Effect of probiotic toothpaste on gingival health in orthodontic patients. Aga Khan University. 2024.
    4. Duraisamy V, Geethapriya PR, Bharath C, Niveditha RS, John JB. Role of probiotics and synbiotics on inhibiting Streptococcus mutans in children – A randomized controlled trial. J Indian Soc Pedod Prev Dent. 2021;39(3):275–278.
    5. Jeong MJ, Cho HA, Kim SY, Kang KR, et al. Assessment of plaque regrowth with a probiotic toothpaste in schoolchildren. J Pediatr Dent. 2017;41(6):434–439.
    6. Maden EA, Altun C, Ozmen B, Basak F. Antimicrobial effect of toothpastes containing fluoride, xylitol, or xylitol probiotic on children’s saliva. Niger J Clin Pract. 2018;21(2):134–138.
    7. Suzuki N, Iwamoto T, Tanabe K, Takeshita T, Hirofuji T. Effects of Lactobacillus salivarius WB21 on halitosis and oral health – a double-blind, randomized, placebo-controlled crossover trial. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;110(2):201–208.
    8. Ding L, Wang Y, Jiang Z, Tang X, et al. Effects of L. salivarius and L. plantarum on halitosis: A double-blind, randomized controlled trial. Food Funct. 2024. doi:10.1039/D4FO02280G
    9. Iwamoto T, Suzuki N, Tanabe K, Takeshita T, Hirofuji T. Effects of probiotic L. salivarius WB21 on breath and gum health – an open-label pilot trial. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010.
    10. Benic GZ, Farella M, Morgan XC, Viswam J, Heng NC, Cannon RD, Mei L. Oral probiotics reduce halitosis in orthodontic patients: A randomized, triple-blind, placebo-controlled trial. J Breath Res. 2019;13(3):036010.
    11. Jiménez E, de Andrés J, Manrique M, Pareja-Tobes P, et al. Ligilactobacillus salivarius PS2 supplementation during pregnancy and lactation prevents mastitis: A randomized controlled trial. Microorganisms. 2021;9(9):1933.
    12. American Academy of Pediatric Dentistry. Caries-risk assessment and management for infants, children, and adolescents. Reference Manual of Pediatric Dentistry. 2024:306–312.
    13. Centers for Disease Control and Prevention (CDC). Fluoride use and pregnancy. CDC, ADA & ACOG Guidelines. 2023.
    14. Sheyholislami H, Connor KL. The safety of probiotics intended for use in pregnant and lactating women: A systematic review and meta-analysis. Nutrients. 2021;13(7):2382.
    15. Doucette H, Ward R, Wheeldon C, Whelan A. The impact of prebiotics and probiotics on the oral microbiome. Can J Dent Hyg. 2024.
    16. Inchingolo F, Mancini A, Inchingolo AD, et al. The benefits of probiotics on oral health: Systematic review of the literature. Pharmaceuticals. 2023.
    17. Bourgeois D, Gonçalves LS, Lima-Junior JC, Carrouel F. The oral microbiome is a key factor in oral and systemic health. Front Microbiol. 2022;13:855668.
    18. Alahmari MM. Comparative efficacy of medium and soft toothbrushes in plaque removal and gingivitis control. Med Sci Monit. 2024;30:e945395.
    19. Langa GPJ, Muniz FWMW, et al. Anti-plaque and anti-gingivitis efficacy of different bristle stiffness and end-shape toothbrushes on interproximal surfaces: A systematic review and meta-analysis. J Evid Based Dent Pract. 2021;21(3):101548.
    20. Ranzan N, Muniz FWMW, Rösing CK. Bristle stiffness and end-shape effects on soft tissue safety: A systematic review. Int Dent J. 2021. doi:10.1111/idj.12421.
    21. Venkatasubramanian R, Reddy KVKK, et al. Evaluation of microbial count between bamboo and plastic toothbrushes used by children over 1 month. Int J Sci Res Microbiol. 2021;10(5):71–74.
    22. Ishii Y, Suzuki I, Sakazume-Suzuki H, Kurakawa Y. Low-environmental-impact bamboo toothbrushes and post-use hygiene. Int J Oral-Med Sci. 2023;22(1):23–34. doi:10.5466/ijoms.22.23.
    23. Agarwal S, Chakraborty R, Modak J, et al. Microbial contamination of toothbrush heads – bamboo vs plastic. Adv Hum Biol. 2024;14(2):102–106. doi:10.4103/aihb.aihb_122_23.
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